Pontus Plavén‐Sigray

Pitfalls of mapping functional and molecular human brain imaging data from separate cohorts

The paper shows that estimating correlations across brain regions from separate cohorts can be misleading due to biases and errors in interpretation.

Single-dose rapamycin increases brain glucose metabolism but reduces synaptic density in Long-Evans rats

This study examines the effects of a single rapamycin dose on brain glucose metabolism and synaptic density in rats using PET imaging, finding increased metabolism and decreased synaptic density.

Multimodal brain age prediction using machine learning: combining structural MRI and 5-HT2AR PET derived features

This study predicts brain age using 5-HT2AR PET and MRI data, finding that combining both improves accuracy compared to using either modality alone.

Prediction of brain age using structural magnetic resonance imaging: A comparison of accuracy and test-retest reliability of publicly available software packages

This study compares six brain age prediction software packages using MRI data, finding pyment and brainageR to be most accurate and reliable.

Kinetic models for PET displacement studies

This paper develops kinetic models for PET displacement studies to estimate target occupancy from a single scan, showing good agreement with traditional methods.

Evaluation of the α-synuclein PET radiotracer (d3)-MODAG-001 in pigs

This paper evaluates the PET radiotracer (d3)-[11C]MODAG-001 in pigs to detect α-synuclein aggregates, showing increased binding in regions with α-synuclein pre-formed fibrils and Alzheimer's homogenate.

An in vivo pig model for testing novel PET radioligands targeting cerebral protein aggregates

The paper develops a pig model for testing PET radioligands targeting cerebral protein aggregates, validated using [11C]PIB uptake in injected regions.

Synaptic density and neuronal metabolic function measured by PET in the unilateral 6-OHDA rat model of Parkinson's disease

This study compares [11C]UCB-J and [18F]FDG PET in a 6-OHDA rat model of Parkinson's disease, finding divergent changes in synaptic density and metabolic function in CSTC circuits.

Low convergent validity of FLB 457

The paper assesses the correlation between [11C]raclopride and [11C]FLB 457 binding potential in extrastriatal brain regions and finds weak to moderate correlations, suggesting caution in using [11C]raclopride for D2-R quantification.

Dopamine D1 receptor availability is not associated with delusional ideation measures of psychosis proneness

The study investigates the association between dopamine D1 receptor availability and delusional ideation in healthy controls using PET and questionnaire data, finding little to no linear association.

Validity and reliability of extrastriatal raclopride binding quantification in the living human brain

This study evaluates the validity and reliability of [11C]raclopride PET for quantifying D2/3R binding outside the striatum, finding it unreliable in extrastriatal regions.

Test-retest reliability and convergent validity of (R)-PK11195 outcome measures without arterial input function

This study evaluates test-retest reliability and convergent validity of (R)-[11C]PK11195 binding measures without arterial input function, finding poor reliability and weak correlations for most methods.

Accuracy and reliability of PBR28 specific binding estimated without the use of a reference region

This study evaluates the accuracy and reliability of specific binding estimates for [11C]PBR28 using the SIME method, showing good precision and reliability for VS but variability in BPND.

A simulation and comparison of dynamic functional connectivity methods

This paper evaluates five DFC methods through simulations and introduces a benchmarking tool for comparing DFC methods.

Is dopamine D1 receptor availability related to social behavior? A positron emission tomography replication study

This study attempts to replicate previous findings linking dopamine D1 receptor availability to social behavior using PET and personality scales but finds no significant correlations.