William Norton

Genome-wide association and multi-omics functional screens reveal the genetic architecture of foveal development

This paper identifies genetic variants and genes associated with foveal hypoplasia using GWAS and multi-omics data, and establishes a zebrafish model to study the condition.

Genetic disruption of leucine rich repeat transmembrane protein 4 like 1 induces a pro-social behavioural phenotype in zebrafish

This study shows that knocking out lrrtm4l1 in zebrafish leads to more social behavior, including cohesive shoaling and reduced aggression.

Environmental Enrichment Reduces adgrl3.1-Related Anxiety and Attention Deficits but Not Impulsivity

This study shows environmental enrichment reduces anxiety and attention deficits but not impulsivity in adgrl3.1 knockout zebrafish, indicating genetic and environmental interactions in behavioral traits.

Social Isolation Intensifies adgrl3.1-Related Externalizing and Internalizing Behaviors in Zebrafish

The paper examines how social isolation interacts with a genetic mutation to intensify both externalizing and internalizing behaviors in zebrafish.

adgrl3.1-deficient zebrafish show noradrenaline-mediated externalizing behaviors, and altered expression of externalizing disorder-candidate genes, suggesting functional targets for treatment

This study shows adgrl3.1-deficient zebrafish exhibit externalizing behaviors rescued by atomoxetine, and identifies differentially expressed genes linked to externalizing disorders.

Pleiotropic contribution of rbfox1 to psychiatric and neurodevelopmental phenotypes in a zebrafish model

This study investigates the behavioral effects of rbfox1 deficiency in zebrafish, finding multiple behavioral changes that resemble those in Rbfox1-deficient mice and psychiatric patients.

Deficiency of the ywhaz gene, involved in neurodevelopmental disorders, alters brain activity and behaviour in zebrafish

This study shows that ywhaz gene deficiency in zebrafish affects brain activity and behavior, with altered neuronal connectivity and monoamine levels.