Author

Vikram Pattanayak

Harvard UniversityORCID 0000-0002-3985-3049Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:human· 2 Research Focus:benchmarking· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Research Focus:perturbation response prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

J. Keith JoungiD· 3 shared Kendell ClementiD· 3 shared Luca PinelloiD· 3 shared Karl PetriiD· 2 shared Martin J. AryeeiD· 2 shared Archana Verma· 1 shared Caleb A. LareauiD· 1 shared Christian BrendeliD· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersMolecular Biology

J. Keith JoungORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Gene editing without ex vivo culture evades genotoxicity in human hematopoietic stem cells

Jing Zeng, My Anh Nguyen, Pengpeng Liu, Lucas Ferreira da Silva, Sébastien Levesque, Linda Yingqi Lin, David G. Justus, Karl Petri, Kendell Clement, Shaina N. Porter, Archana Verma, Nola R. Neri, Tolulope O. Rosanwo, Marioara-Felicia Ciuculescu, Daniela Abriss, , Daniel E. Bauer

This study shows that gene editing of HSCs without ex vivo culture reduces genotoxicity while maintaining therapeutic efficacy for beta-hemoglobinopathy treatment.

Cell stem cell · Dec 12, 2024Peer-reviewedGenetics

Global-scale CRISPR gene editor specificity profiling by ONE-seq identifies population-specific, variant off-target effects

Karl Petri, Daniel Y. Kim, Kanae E. Sasaki, Matthew C. Canver, Xiao Wang, Hina Shah, Hyunho Lee, Joy E. Horng, Kendell Clement, Sowmya Iyer, Sara P. Garcia, Jimmy A. Guo, Gregory A. Newby, Luca Pinello, David R. Liu, , Vikram Pattanayak

ONE-seq identifies population-specific off-target effects of CRISPR gene editors using global human genome sequence diversity.

bioRxiv · Apr 5, 2021 · PreprintMolecular Biology

"Unexpected mutations after CRISPR-Cas9 editing in vivo" are most likely pre-existing sequence variants and not nuclease-induced mutations

Caleb A. Lareau, Kendell Clement, Jonathan Y. Hsu, Vikram Pattanayak, J. Keith Joung, Martin J. Aryee, Luca Pinello

The paper challenges the claim that CRISPR-Cas9 induces off-target mutations by showing that the observed variants are likely pre-existing genetic differences between treated mice and the control.

Nature Methods · Mar 30, 2018Peer-reviewedMolecular Biology