Author

Kanae E. Sasaki

Massachusetts General HospitalORCID 0000-0002-6630-3552Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:benchmarking· 1 Assay:CRISPR screen· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Aamir MiriD· 1 shared Alexander H. SettleiD· 1 shared Alexandra M. Lied· 1 shared Alireza EdrakiiD· 1 shared Ankit GuptaiD· 1 shared Chris K. FulleriD· 1 shared Daniel Y. KimiD· 1 shared David R. LiuiD· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperMolecular Biology

Aamir MirORCID

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2 papers

Recent·Most cited

Global-scale CRISPR gene editor specificity profiling by ONE-seq identifies population-specific, variant off-target effects

Karl Petri, Daniel Y. Kim, Kanae E. Sasaki, Matthew C. Canver, Xiao Wang, Hina Shah, Hyunho Lee, Joy E. Horng, Kendell Clement, Sowmya Iyer, Sara P. Garcia, Jimmy A. Guo, Gregory A. Newby, Luca Pinello, David R. Liu, , Vikram Pattanayak

ONE-seq identifies population-specific off-target effects of CRISPR gene editors using global human genome sequence diversity.

bioRxiv · Apr 5, 2021 · PreprintMolecular Biology

NmeCas9 is an intrinsically high-fidelity genome editing platform

Nadia Amrani, Xin D. Gao, Pengpeng Liu, Alireza Edraki, Aamir Mir, Raed Ibraheim, Ankit Gupta, Kanae E. Sasaki, Tong Wu, Paul D. Donohoue, Alexander H. Settle, Alexandra M. Lied, Kyle McGovern, Chris K. Fuller, Peter Cameron, , Erik J. Sontheimer

The paper demonstrates that NmeCas9, a Cas9 ortholog, exhibits high-fidelity genome editing in human cells with minimal off-target effects and multiple PAM compatibility.

Genome biology · Dec 1, 2018Peer-reviewedMolecular Biology