Cancer BiologybioRxivPreprint
Acid ceramidase inhibition enhances BCL-2 targeting in venetoclax-resistant acute myeloid leukemia via a cytotoxic integrated stress response
Johnson Ung, Su‐Fern Tan, Jeremy J.P. Shaw…·Thomas P. Loughran
This study shows that inhibiting acid ceramidase (AC) enhances venetoclax's effectiveness in venetoclax-resistant AML by inducing a cytotoxic integrated stress response.
DOI 10.1101/2025.06.06.657881