Author

Kumar Dilip Ashtekar

Yale Cancer CenterORCID 0000-0001-8264-6558Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Approach:machine learning (classical)· 1 Approach:mechanistic / dynamical model· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

Mark A. LemmoniD· 2 shared Yuko TsutsuiiD· 2 shared Debdas DhabaliD· 1 shared Hrishabh Singh· 1 shared Keshav PatiliD· 1 shared Krishna SureshiD· 1 shared Ravi RadhakrishnaniD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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2 shared papersBiophysics

Mark A. LemmonORCID

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2 papers

Recent·Most cited

BiophysicsbioRxivPreprintOct 14, 2024

EGFR and tyrosine kinase inhibitor interactions probed by hydrogen-deuterium exchange and mass spectrometry (HDX-MS)

Kumar Dilip Ashtekar, Mark A. Lemmon, Yuko Tsutsui

This study uses HDX-MS to analyze EGFR dynamics upon TKI binding, revealing inhibitor-dependent structural changes that correlate with side effects and covalent inhibitor selectivity.

DOI 10.1101/2024.10.14.618277

humanproteomics

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BiophysicsbioRxivPreprintOct 4, 2024

Coupled Solvent and Protein Dynamics Confer Differences in Exon-19 Deletion Mutants of the Epidermal Growth Factor Receptor Kinase

Keshav Patil, Debdas Dhabal, Kumar Dilip Ashtekar…·Ravi Radhakrishnan

This study identifies two mutation profiles in EGFR Exon-19 deletions that correlate with differential TKI sensitivity through analysis of conformational dynamics and solvent interactions.

DOI 10.1101/2024.10.04.616731

humanprotein structure

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