Author

Shruti Sridhar

National University of SingaporeORCID 0000-0002-0388-0352Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Anand Devaprasath D. JeyasekharaniD· 2 shared Chartsiam TipgomutiD· 2 shared Claudio TripodoiD· 2 shared Patrick William JaynesiD· 2 shared Arvind RaoiD· 1 shared Ashley P. TsangiD· 1 shared Brian J. LaneiD· 1 shared Char Loo TaniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Anand Devaprasath D. JeyasekharanORCID

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Author profile →

2 papers

Recent·Most cited

A lipid-laden macrophage niche drives immunosuppression in primary central nervous system lymphoma

Liang Hong, Subhashini Joshi, Min Liu, Shruti Sridhar, Maria Victoria Revuelta, Zi Yan Charmaine Ong, Norbert S. C. Tay, Wei Xian Clemence Lai, Chartsiam Tipgomut, Patrick William Jaynes, Yanfen Peng, Char Loo Tan, Susan Swee‐Shan Hue, Siok-Bian Ng, Sanjay De Mel, , Anand Devaprasath D. Jeyasekharan

This study identifies lipid-laden macrophages as an immunosuppressive niche in PCNSL, validated through spatial transcriptomics and mouse models, and shows SYK inhibition reverses their tumor-supportive activity.

bioRxiv · Sep 1, 2026 · PreprintCancer Biology

PatternExtract: A facile, scalable pipeline for point pattern generation from spatial imaging data

Shruti Sridhar, Gayatri Kumar, Victoire Ringler, Kanav Gupta, Siddham Jasoria, Ziwei Meng, Patrick William Jaynes, Chartsiam Tipgomut, Vaibhav Rajan, David Scott, Claudio Tripodo, Kasthuri Kannan, Anand Devaprasath D. Jeyasekharan

PatternExtract generates spatial point patterns from pathology images and cell coordinates using a two-kernel segmentation method and automated classification, validated on lymphoma data.

Computational and Structural Biotechnology Journal · Jan 1, 2026Peer-reviewedBioinformatics