Structural basis of Drosophila insulin receptor activation by DILP2 hormone
Talha Shafi, Olga V. Moroz, Huw T. Jenkins, Maria Chechik, Michail N. Iusupov, Marta Lubos, Jiřı́ Jiráček, Pierre DE MEYTS, Andrzej Marek Brzozowski
This study presents two cryo-EM structures of the Drosophila insulin receptor ectodomain bound to DILP2, revealing structural and kinetic differences in hormone binding.
Open Biology · Jun 17, 2026Peer-reviewedBiochemistry