Jiřı́ Jiráček

This study develops synthetic PAPP-A inhibitors that modulate IGF signaling in vitro and in vivo, showing efficacy comparable to natural inhibitors.

This study presents two cryo-EM structures of the Drosophila insulin receptor ectodomain bound to DILP2, revealing structural and kinetic differences in hormone binding.

This paper reveals how insulin mimetics stabilize the insulin receptor in a novel apo-state that prevents activation by blocking signal transduction.

The paper develops a non-radioactive screening assay for insulin receptor ligands that is faster and more sensitive than existing radioligand assays.