Marta Lubos

Synthetic inhibitors of pregnancy-associated plasma protein-A regulate IGF-1 signaling in vitro and in vivo

This study develops synthetic PAPP-A inhibitors that modulate IGF signaling in vitro and in vivo, showing efficacy comparable to natural inhibitors.

Structural basis of Drosophila insulin receptor activation by DILP2 hormone

This study presents two cryo-EM structures of the Drosophila insulin receptor ectodomain bound to DILP2, revealing structural and kinetic differences in hormone binding.

Antagonistic insulin mimetics lock the insulin receptor in an alternative apo-state

This paper reveals how insulin mimetics stabilize the insulin receptor in a novel apo-state that prevents activation by blocking signal transduction.