The paper identifies novel recessive loci affecting lactation traits in cattle using non-additive QTL mapping on 124,000 sequence-imputed cows, revealing differences in genetic architecture between milk yield and composition traits.

Genetics Selection Evolution · Jan 24, 2022Peer-reviewedGenetics

A new mechanism for a familiar mutation - bovine DGAT1 K232A modulates gene expression through multi-junction exon splice enhancement

Tania Fink, Thomas Lopdell, Kathryn Tiplady, Renée R. Handley, Thomas Johnson, Richard J. Spelman, Stephen R. Davis, Russell G. Snell, Mathew D. Littlejohn

The paper re-examines the mechanism of the DGAT1 K232A mutation in bovine milk production, showing it modulates gene expression through splicing enhancement.

BMC Genomics · Aug 26, 2020Peer-reviewedMolecular Biology

Multiple QTL underlie milk phenotypes at the CSF2RB locus

Thomas Lopdell, Kathryn Tiplady, Christine Couldrey, Thomas Johnson, Michael Keehan, Stephen R. Davis, B.L. Harris, Richard J. Spelman, Russell G. Snell, Mathew D. Littlejohn

The paper identifies multiple QTL at the CSF2RB locus associated with milk yield and composition traits in dairy cattle and explores their genetic and molecular mechanisms.

Genetics Selection Evolution · Jan 24, 2019Peer-reviewedGenomics

Widespread cis-regulation of RNA-editing in a large mammal

Thomas Lopdell, Victoria Hawkins, Christine Couldrey, Kathryn Tiplady, Stephen R. Davis, B.L. Harris, Russell G. Snell, Mathew D. Littlejohn

The paper identifies cis-regulated RNA editing quantitative trait loci (edQTL) in cattle, linking them to gene expression and lactation traits.

RNA · Dec 10, 2018Peer-reviewedGenomics