Jean Hausser

IntegrAlign integrates multiimmunofluorescence panels through image alignment, achieving sub-cellular precision and improving spatial analysis of tumor microenvironments.

This study uses longitudinal scRNAseq to analyze temporal dynamics of the tumor microenvironment in mouse breast tumors, identifying three patterns of multi-cellular phenotypic changes during progression.

The paper identifies four tumor micro-environmental niches that explain inter-patient variation in breast tumor cellular composition using single-cell profiling and imaging data.

The paper investigates the trade-off between precision and economy in gene expression rates and finds that certain rate combinations are missing due to selective pressures.

The paper introduces a theoretical framework to understand tumor diversity by identifying universal cancer tasks and showing driver mutations influence gene-expression specialization.

The paper shows that protein degradation, not just transcription, drives coordinated fluctuations in protein abundance in single cells.