Author

Wolfgang Link

Consejo Superior de Investigaciones CientíficasORCID 0000-0002-3340-5165Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Approach:statistical model· 2

Frequent Co-Authors

Bibiana I. FerreiraiD· 4 shared Lucía JiméneziD· 2 shared Víctor Mayoral-VaroiD· 2 shared Alba Orea‐SoufiiD· 1 shared Ana Luísa De Sousa‐CoelhoiD· 1 shared Ana-Teresa MaiaiD· 1 shared André Besouro-Duarte· 1 shared Andrea Grijalva-Bravo· 1 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersCancer Biology

Bibiana I. FerreiraORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

INPP5E interactome reveals novel connections to growth factor signaling

Raquel Martin-Morales, Pablo Barbeito, Belén Sierra‐Rodero, Lucía Jiménez, Maria Schrøder Holm, Andrea Grijalva-Bravo, Darío Cilleros-Rodríguez, Lena K. Ebert, Matilde Cortabarría Fernandez, Lotte Bang Pedersen, José Luis Badano, Florencia Irigoı́n, Bernhard Schermer, Wolfgang Link, Søren T. Christensen, Francesc R. García-Gonzalo

This study identifies INPP5E interactors involved in growth factor signaling, revealing its role in regulating ciliary pathways in fibroblasts.

Cell Communication and Signaling · Aug 31, 2026Peer-reviewedBiochemistry

Resistance to Carcinogenesis in the African Spiny Mouse (Acomys) correlates with upregulation of tumor suppressor genes.

Marta Vitorino, Gonçalo G. Pinheiro, Inês Grenho, Inês M. Araújo, Bibiana I. Ferreira, Wolfgang Link, Gustavo Tiscórnia

This study compares tumor resistance between Acomys and Mus mice after carcinogen treatment, finding Acomys upregulates tumor suppressor genes and immune-related processes.

Scientific Reports · May 2, 2026Peer-reviewedCancer Biology

Combined expression of FOXO and Tribbles proteins predicts survival of glioma patients

Bruno F. Santos, Ana-Teresa Maia, Inês Grenho, André Besouro-Duarte, Juan M Sepúlveda, Bibiana I. Ferreira, Wolfgang Link

This paper identifies a FOXO/Tribbles mRNA signature that predicts poor survival in glioma patients, particularly in grade 4 gliomas, across multiple cohorts.

Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · Jan 1, 2026Peer-reviewedCancer Biology

TRIB2 supports a high glycolytic phenotype in melanoma cells

Víctor Mayoral-Varo, Ana Luísa De Sousa‐Coelho, Carla Lopes, Óscar H. Martínez-Costa, Paulo Jorge Oliveira, Juan J. Aragón, Bibiana I. Ferreira, Wolfgang Link

This study shows TRIB2 promotes glycolysis in melanoma cells, contributing to therapy resistance and suggesting it as a potential therapeutic target.

bioRxiv · Nov 18, 2025 · PreprintCancer Biology

Pharmacological Modulation of TRIB2 Stability in Melanoma Reveals CDK12/13 as Dominant Regulators and Potential Therapeutic Targets

Víctor Mayoral-Varo, Alba Orea‐Soufi, Lucía Jiménez, Bruno Santos, Carlos Amenabar, Panagiota Kyriakou, Gisela Serrão, Miguel Jociles, Sara Obeso, Cristina Garnés-García, Pablo Fernández-Aroca, Ricardo Sánchez‐Prieto, Bibiana I. Ferreira, Wolfgang Link

This study identifies CDK12/13 as key regulators of TRIB2 stability in melanoma and presents three classes of compounds that effectively eliminate TRIB2 with higher potency than afatinib.

bioRxiv · Jul 17, 2024 · PreprintCancer Biology