Xinhong Chen

The paper identifies AAV vectors that efficiently deliver transgenes to the nervous systems of spiny mice, enabling functional studies of regeneration.

The paper uses Perturb-seq in mice to identify genes that promote collateral artery formation by comparing gene expression between guinea pigs and mice.

This study engineers AAVs targeting human carbonic anhydrase IV to enhance brain gene delivery, finding that optimized variants achieve 100-fold greater transduction than AAV9.

The paper identifies transcriptional crosstalk between enhancers and promoters delivered by AAVs, showing concatemer formation enables targeted delivery of large genetic cargo for cell-type-specific gene editing.

This paper introduces VISTA, a label-free vibrational imaging technique that achieves high-resolution imaging of biological structures with 82 nm resolution and enables unbiased, high-throughput tissue analysis.

This study shows that dorsal raphe dopamine neurons encode motivational salience, responding to reward and punishment cues and modulated by internal and external states.