Author

John Rizk

University of CopenhagenORCID 0000-0002-3352-5474Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Organism:Drosophila· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

Mads Gyrd‐HanseniD· 2 shared Rune Busk DamgaardiD· 2 shared Akhee Sabiha JahaniD· 1 shared Alexander FruehiD· 1 shared Anna L. AaltoiD· 1 shared Anna M. DahlströmiD· 1 shared Annika MeinanderiD· 1 shared Berthe Katrine FiiliD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersMolecular Biology

Mads Gyrd‐HansenORCID

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2 papers

Recent·Most cited

The binding of OTULIN restrains LUBAC activity to prevent TNF-driven immunopathology

Wenxin Lyu, Berthe Katrine Fiil, John Rizk, Majken Kjær, Max Benjamin Sauerland, Biao Ma, Malin Jessen, Rune Busk Damgaard, Mads Gyrd‐Hansen

This study shows that OTULIN's interaction with LUBAC limits its activity, preventing TNF-driven inflammation and immunopathology.

bioRxiv · Feb 28, 2026 · PreprintMolecular Biology

M1-linked Ubiquitination by LUBAC Regulates AMPK Activity and the Response to Energetic Stress

Camilla Reiter Elbæk, Sophie Gradinaru, Anna M. Dahlström, Alexander Frueh, Akhee Sabiha Jahan, Joyceline Cuenco, Anna L. Aalto, John Rizk, Simon A. Hawley, Sarah N. J. Franks, Michael Stumpe, Srinivasa Prasad Kolapalli, Chris Kedong Wang, Cara J. Ellison, Ximena Hildebrandt, , Rune Busk Damgaard

This study shows LUBAC activates AMPK and OTULIN restricts it, affecting metabolic responses to energy stress in cells, mice, and flies.

Cell Death and Differentiation · Feb 13, 2026Peer-reviewedCell Biology