Petar Podlesniy

Unscheduled DNA synthesis reveals a DNA repair hotspot and biomarker of somatic instability at the expanded-CAG repeat tract in the huntingtin gene

The paper develops URSA, a method to quantify DNA repair activity at the CAG repeat tract in HD, showing it correlates with somatic instability and can be measured rapidly in blood cells.

Alpha-synuclein overexpression triggers divergent cellular responses and post-translational modifications in SH-SY5Y and ReNcell VM models

This study shows that alpha-synuclein overexpression causes different cellular responses and post-translational modifications in two neuronal cell models, highlighting context-dependent vulnerability in Parkinson's disease.

Molecular Basis for Maternal Inheritance of Human Mitochondrial DNA

The paper identifies the molecular mechanism by which human sperm mitochondria lack mtDNA and how TFAM re-localization leads to paternal mtDNA elimination.