Author

Samantha Howerton

Virginia TechORCID 0000-0002-3379-0593Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

Aizhen Xiao· 1 shared Alexis Petrosky· 1 shared Austin Hoggarth· 1 shared Benjamin W. PurowiD· 1 shared Caleb A. StineiD· 1 shared Caroline O’BrieniD· 1 shared Cora EsparzaiD· 1 shared Ian F. KimbroughiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Aizhen Xiao

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1 paper

Recent·Most cited

S1PR3 mediates glial stimulated tumor invasion in response to interstitial fluid flow

R. Chase Cornelison, Samantha Howerton, Kinsley M. Tate, Caleb A. Stine, Alexis Petrosky, Kathryn M. Kingsmore, Sharon K. Michelhaugh, Jessica J. Cunningham, Katie Degen, Austin Hoggarth, Cora Esparza, Peng Jin, Maosen Wang, Caroline O’Brien, Aizhen Xiao, , Jennifer M. Munson

This study shows interstitial fluid flow upregulates S1PR3 in glial cells, promoting glioma invasion, and demonstrates that targeting S1PR3 can limit tumor progression.

bioRxiv · Dec 3, 2025 · PreprintCancer Biology