S1PR3 mediates glial stimulated tumor invasion in response to interstitial fluid flow
R. Chase Cornelison, Samantha Howerton, Kinsley M. Tate, Caleb A. Stine, Alexis Petrosky, Kathryn M. Kingsmore, Sharon K. Michelhaugh, Jessica J. Cunningham, Katie Degen, Austin Hoggarth, Cora Esparza, Peng Jin, Maosen Wang, Caroline O’Brien, Aizhen Xiao, , Jennifer M. Munson
This study shows interstitial fluid flow upregulates S1PR3 in glial cells, promoting glioma invasion, and demonstrates that targeting S1PR3 can limit tumor progression.
bioRxiv · Dec 3, 2025 · PreprintCancer Biology