Author

Aizhen Xiao

University of Virginia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Benjamin W. PurowiD· 2 shared 5· 1 shared Adam H. Libby· 1 shared AeRyon KimiD· 1 shared Alexis Petrosky· 1 shared Austin Hoggarth· 1 shared Caleb A. StineiD· 1 shared Caroline O’BrieniD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

Benjamin W. PurowORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Stereoselective Degradation of Diacylglycerol Kinases Potentiate T cell Activation and Tumor Cell Cytotoxicity

Minhaj Shaikh, Surya Pravo Mookherjee, Claire C. Weckerly, Adam H. Libby, Aizhen Xiao, Yunge Zhao, Sagar D. Vaidya, AeRyon Kim, Zhihong Li, Madeleine L. Ware, Michelle Marants, Olivia L. Murtagh, 5, Timothy N. J. Bullock, Benjamin W. Purow, , Ku-Lung Hsu

This study identifies a stereoselective DGK inhibitor that enhances T cell activation and tumor cell cytotoxicity through proteasome-dependent degradation of DGK.

bioRxiv · Dec 12, 2025 · PreprintBiochemistry

S1PR3 mediates glial stimulated tumor invasion in response to interstitial fluid flow

R. Chase Cornelison, Samantha Howerton, Kinsley M. Tate, Caleb A. Stine, Alexis Petrosky, Kathryn M. Kingsmore, Sharon K. Michelhaugh, Jessica J. Cunningham, Katie Degen, Austin Hoggarth, Cora Esparza, Peng Jin, Maosen Wang, Caroline O’Brien, Aizhen Xiao, , Jennifer M. Munson

This study shows interstitial fluid flow upregulates S1PR3 in glial cells, promoting glioma invasion, and demonstrates that targeting S1PR3 can limit tumor progression.

bioRxiv · Dec 3, 2025 · PreprintCancer Biology