Weijia Feng

This study investigates the role of small extrachromosomal circular DNA (eccDNA) in colorectal cancer, finding that it contributes to gene expression, immune cell recruitment, and poor patient outcomes.

The paper develops a method to generate oncogene-carrying ecDNAs in human cells and studies their expression and stability under different conditions.

This study identifies and characterizes over one million urinary cell free eccDNAs in healthy adults, revealing their genomic distribution, sequence features, and potential role of direct repeats in their biogenesis.