Author

Gretchen L. Gierach

National Institutes of HealthORCID 0000-0002-0165-5522Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Alejandro A. SchäfferiD· 1 shared Alexandra R. HarrisiD· 1 shared Andrew Martinez· 1 shared Aravind SrinivasaniD· 1 shared Binbin WangiD· 1 shared Chi‐Ping DayiD· 1 shared Eytan RuppiniD· 1 shared Francis MakokhaiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBioinformatics

Alejandro A. SchäfferORCID

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1 paper

Recent·Most cited

Single-cell-guided identification of logic-gated antigen combinations for designing effective and safe CAR therapy

Sanna Madan, Tiangen Chang, Alexandra R. Harris, Huaitian Liu, Andrew Martinez, Saugato Rahman Dhruba, Binbin Wang, Padma Sheila Rajagopal, Sanju Sinha, Aravind Srinivasan, Simon Knott, Shahin Sayed, Francis Makokha, Chi‐Ping Day, Gretchen L. Gierach, , Eytan Ruppin

This paper introduces LogiCAR designer, a computational method using single-cell transcriptomics to identify logic-gated antigen combinations for CAR therapy, showing improved efficacy and safety compared to existing approaches.

bioRxiv · Mar 19, 2025 · PreprintBioinformatics