Inga V. Hochheiser

This study shows that NLRP3 directly senses intracellular potassium ions, with K+ levels regulating its conformation and inflammasome activation.

This paper characterizes BAL-0028, a novel NLRP3 inhibitor with a distinct binding site and mechanism, showing potent inhibition of human and primate NLRP3 and efficacy in a peritonitis model.

This paper identifies and characterizes BAL-1516, a CNS-penetrating NLRP3 inhibitor that blocks inflammasome formation and shows potential for treating neuroinflammatory diseases.

The paper identifies two distinct NLRP3 activation pathways, one dependent on decameric cage formation and another independent of the MTOC and TGN.