Axel Poulet

This study investigates systemic RNAi in planarians, finding that it relies on active stem cells and Argonaute-siRNA complexes, without RNA amplification or transgenerational effects.

The paper identifies two types of piRNA clusters in planarians, Seed and Spread clusters, which balance piRNA diversity with off-target effect limitation through distinct mechanisms.

This study shows that H3.1K27M disrupts chromatin maturation, leading to TSK/TONSL activation and genomic instability in Arabidopsis.

This study shows that HNRNPU deficiency causes chromatin remodeling, transcriptional changes, and delayed neurogenesis in hindbrain-derived neural progenitors.

NODeJ is an ImageJ plugin that automates 3D segmentation of nuclear objects, improving efficiency and reducing bias in analyzing chromatin organization.

The paper defines RT states as cell type-specific replication timing profiles using a Hidden Markov Model and finds they provide new functional insights into the human genome.