The conformational landscape of human transthyretin revealed by cryo-EM
Benjamin Basanta, Karina Nugroho, N. Yan, Gabriel M. Kline, Evan T. Powers, Felix J. Tsai, Mengyu Wu, Althea Hansel-Harris, Jason S. Chen, Stefano Forli, Jeffery W. Kelly, Gabriel C. Lander
This study uses cryo-EM to reveal the conformational landscape of human transthyretin, uncovering asymmetries and new states relevant to ligand binding and amyloid formation.
Nature Structural & Molecular Biology · Jan 22, 2025Peer-reviewedMolecular Biology