Author

Gabriel M. Kline

Scripps Research InstituteORCID 0000-0002-6960-1299Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

Jeffery W. KellyiD· 2 shared Adrian M. GuerreroiD· 1 shared Althea Hansel-HarrisiD· 1 shared Benjamin BasantaiD· 1 shared Evan T. PowersiD· 1 shared Felix J. TsaiiD· 1 shared Gabriel C. LanderiD· 1 shared Gabrielle CruziD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCell Biology

Jeffery W. KellyORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivApr 4, 2025

Phenylhydrazone-based Endoplasmic Reticulum Proteostasis Regulator Compounds with Enhanced Biological Activity

Gabriel M. Kline, Lisa Boinon, Adrian M. Guerrero…·R. Luke Wiseman

This study identifies AA263 analogs that enhance ER proteostasis by targeting ER protein disulfide isomerases, correcting protein misfolding in disease models.

DOI 10.7554/elife.107000

humanproteomics

𝕏 PostBluesky

Molecular BiologyNature Structural & Molecular BiologyPeer-reviewedJan 22, 2025

The conformational landscape of human transthyretin revealed by cryo-EM

Benjamin Basanta, Karina Nugroho, N. Yan…·Gabriel C. Lander

This study uses cryo-EM to reveal the conformational landscape of human transthyretin, uncovering asymmetries and new states relevant to ligand binding and amyloid formation.

26 citationstop 2%

humanprotein structure

𝕏 PostBluesky