Althea Hansel-Harris

This study shows that inhibiting SagA, a peptidoglycan hydrolase, increases vancomycin susceptibility in VREfm through both genetic and pharmacological approaches.

This study determines the structural properties of full-length IMP2, revealing its dimeric conformation and RNA-induced changes, which may inform drug design.

This study identifies DCA as a microbiota-derived bile acid that activates STING and enhances antitumor immunity via NK cell activation.

The paper develops fluorescent probes for FphB, a Staphylococcus aureus enzyme, using mRNA display with a genetically encoded electrophile, achieving nanomolar selectivity.

This study uses cryo-EM to reveal the conformational landscape of human transthyretin, uncovering asymmetries and new states relevant to ligand binding and amyloid formation.