Design principles of the common Gly-X6-Gly membrane protein building block
Kiana Golden, Catalina Avarvarei, Charlie T. Anderson, Matthew Holcomb, Weiyi Tang, Xiaoping Dai, Minghao Zhang, Colleen A. Maillie, Brittany B. Sanchez, Jason S. Chen, Stefano Forli, Marco Mravic
The paper uses protein design to investigate the structural principles of common antiparallel transmembrane motifs, revealing how sequence patterns stabilize membrane protein architectures.
Proceedings of the National Academy of Sciences · Oct 7, 2025Peer-reviewedBiophysics