Author

Anca Flavia Savulescu

University of Cape TownORCID 0000-0002-3428-0157Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Immunology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:spatial transcriptomics· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1 Assay:protein structure· 1

Frequent Co-Authors

Benjamin DartiguesiD· 2 shared Emmanuel BouilholiD· 2 shared Macha NikolskiiD· 2 shared Musa M. MhlangaiD· 2 shared Robyn Brackin· 2 shared Abhimanyu AbhimanyuiD· 1 shared C. Ronald KahniD· 1 shared Edgar Lefevre· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBioinformatics

Benjamin DartiguesORCID

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3 papers

Recent·Most cited

ImmunologybioRxivPreprintMay 19, 2025

Protein Kinase C δ: a critical hub regulating macrophage immunomodulatory functions during Mycobacterium tuberculosis infection

Rudranil Hazra, Mumin Ozturk, Nashied Peton…·Suraj P. Parihar

This study investigates the role of PKCδ in macrophage immunomodulation during Mtb infection, finding that its deficiency leads to increased Mtb burden and exacerbated pathology.

DOI 10.1101/2025.05.19.653976

mouseexperimental assay

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BioinformaticsBiological ImagingPeer-reviewedJan 1, 2022

DeepSpot: a deep neural network for RNA spot enhancement in smFISH microscopy images

Emmanuel Bouilhol, Anca Flavia Savulescu, Edgar Lefevre…·Macha Nikolski

DeepSpot enhances RNA spots in smFISH images using deep learning, enabling automated detection without manual parameter tuning and achieving over 97% accuracy.

21 citations

mousespatial transcriptomics

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Systems BiologybioRxivPreprintJan 31, 2019

DypFISH: Dynamic Patterned FISH to Interrogate RNA and Protein Spatial and Temporal Subcellular Distribution

Anca Flavia Savulescu, Robyn Brackin, Emmanuel Bouilhol…·Musa M. Mhlanga

DypFISH quantitatively investigates spatial and temporal subcellular localization of RNA and protein using micropatterning and fluorescence microscopy, revealing reproducible patterns and dynamics.

5 citations

spatial transcriptomicsprotein structure

𝕏 PostBluesky