This study investigates the effects of NOTCH3 suppression in human vascular smooth muscle cells, revealing changes in extracellular matrix, cytoskeletal organization, and metabolic pathways.

bioRxiv · Aug 28, 2026 · PreprintMolecular Biology

Genome-wide meta-analysis and omics integration identifies novel genes associated with diabetic kidney disease

Niina Sandholm, Joanne B. Cole, Viji Nair, Xin Sheng, Hongbo Liu, Emma Ahlqvist, Natalie R. van Zuydam, Emma H. Dahlström, Damian Fermin, Laura Jane Smyth, Rany M. Salem, Carol M. Forsblom, Erkka Valo, Valma Harjutsalo, Eoin Patrick Brennan, , Per‐Henrik Groop

Diabetologia · Jun 28, 2022Peer-reviewedGenetic & Genomic Medicine

Assessment of differentially methylated loci in individuals with end-stage kidney disease attributed to diabetic kidney disease

Laura Jane Smyth, Jill Kilner, Viji Nair, Hengxi Liu, Eoin Patrick Brennan, Katie Kerr, Niina Sandholm, Joanne B. Cole, Emma H. Dahlström, Anna Syreeni, Rany M. Salem, Robert G. Nelson, Helen C. Looker, Christopher Wooster, Kerry Anderson, , Amy Jayne McKnight

The paper identifies differentially methylated loci in individuals with end-stage kidney disease due to diabetic kidney disease, linking them to key pathways and genes.

Clinical Epigenetics · May 1, 2021Peer-reviewedMolecular Biology