SET1B drives sustained HIF activity and disease progression in clear cell renal cell carcinoma.
Brian M. Ortmann, Tekle Pauzaite, James A.C. Bertlin, Rachel Seear, Esther Arnaiz, Lukasz W. Marzec, Alexander Handyside, Laura M. Bowker, Sarah E. Barnett, Katherine Harcourt, Salwa Lin, Ahmed M. Salman, Laura Wilson, Adrian Llewellyn Harris, Grant Duncan Stewart, , James A. Nathan
This study shows SET1B maintains HIF activity in ccRCC, correlates with disease progression, and is a target for HIF-2 inhibitors.
Cancer Research · Apr 6, 2026Peer-reviewedCancer Biology