This paper develops a xeno-free human iPSC-derived prostate organoid platform that enables multilineage differentiation and genetic manipulation for studying prostate biology and disease.

Cell Reports Methods · Jul 29, 2026Peer-reviewedCell Biology

SET1B drives sustained HIF activity and disease progression in clear cell renal cell carcinoma.

Brian M. Ortmann, Tekle Pauzaite, James A.C. Bertlin, Rachel Seear, Esther Arnaiz, Lukasz W. Marzec, Alexander Handyside, Laura M. Bowker, Sarah E. Barnett, Katherine Harcourt, Salwa Lin, Ahmed M. Salman, Laura Wilson, Adrian Llewellyn Harris, Grant Duncan Stewart, , James A. Nathan

This study shows SET1B maintains HIF activity in ccRCC, correlates with disease progression, and is a target for HIF-2 inhibitors.

Cancer Research · Apr 6, 2026Peer-reviewedCancer Biology

Loss of ARID1A accelerates prostate tumourigenesis with a proliferative collagen-poor phenotype through co-operation with AP1 subunit cFos

Andrew Hartley, Laura C.A. Galbraith, Robin Shaw, Amy J. Tibbo, Rajan Veeratterapillay, Laura Wilson, Rakesh Heer, Karen Blyth, Hing Y. Leung, Imran Ahmad

This study identifies Arid1a loss as a driver of aggressive prostate cancer in mice, accelerating tumorigenesis and promoting a proliferative, collagen-poor phenotype through cooperation with cFos.

British Journal of Cancer · Jan 30, 2025Peer-reviewedCancer Biology

High-throughput propagation of human prostate tissue from induced-pluripotent stem cells

Anastasia C. Hepburn, Emma L. Curry, Mohammad Moad, Rebecca E. Steele, Omar E. Franco, Laura Wilson, Parmveer Singh, Adriana Buskin, Susan E. Crawford, Luke Gaughan, Ian Geoffrey Mills, Simon W. Hayward, Craig N. Robson, Rakesh Heer

This paper introduces a high-throughput method to generate human prostate tissue from induced pluripotent stem cells using co-culture with urogenital sinus mesenchyme.

Stem Cells Translational Medicine · Mar 14, 2020Peer-reviewedDevelopmental Biology