This study shows SARS-CoV-2 infection of human neural cells is non-permissive but causes inflammation and cell damage, suggesting neural damage in COVID-19 is due to systemic inflammation rather than direct viral replication.

Stem Cell Research · Jun 20, 2021Peer-reviewedNeuroscience

Oligomeric α-Synuclein induces skin degeneration in a reconstructed human epidermis model

Júlia Teixeira Oliveira, Rodrigo De Vecchi, Vanja Dakic, Gabriela Vitória, Carolina Pedrosa, Mayara Abud Mendes, Luiz Guilherme H. S. Aragão, Thyago R. Cardim-Pires, Daniel Rodrigues Furtado, Roberta Olmo Pinheiro, Débora Foguel, Lionel Breton, Charbel Bouez, Marília Zaluar P. Guimarães, Stevens Kastrup Rehen

This study shows that oligomeric α-synuclein reduces keratinocyte proliferation and induces inflammation in a reconstructed human epidermis model.

bioRxiv · Jun 17, 2021 · PreprintNeuroscience

Quantitative profiling of axonal guidance proteins during the differentiation of human neurospheres

Livia Goto‐Silva, Michele Rodrigues Martins, Jimmy Rodriguez Murillo, Letícia R. Q. Souza, Gabriela Vitória, Júlia Teixeira Oliveira, Juliana Minardi Nascimento, Erick Correia Loiola, Fábio César Sousa Nogueira, Gilberto B. Domont, Marília Zaluar P. Guimarães, Fernanda Freire Tovar-Moll, Stevens Kastrup Rehen, Magno Junqueira

This study quantifies proteomic changes during human neurosphere differentiation, identifying upregulated axon guidance pathways and a functional assay for neurite outgrowth.

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · Apr 20, 2021Peer-reviewedNeuroscience