The biophysical mechanism of mitochondrial pearling
Gabriel Sturm, Kayley Hake, Austin E.Y.T. Lefebvre, Caleb J. Rux, Daria Ivanova, Alfred Millett-Sikking, Kevin M. Tharp, Beiduo Rao, Michael Closser, Adam James Waite, Magdalena Preciado López, Alex T. Ritter, Sophie Dumont, Wen Jing Lu, Suliana Manley, , Wallace F. Marshall
This study identifies a biophysical mechanism for mitochondrial pearling, showing it occurs spontaneously in various cell types and is driven by internal pressure or external tension.
Molecular Biology of the Cell · Oct 8, 2025Peer-reviewedCell Biology