Gabriel Sturm

The paper presents a multimodal perturbation atlas using CRISPR knockouts in A549 cells, combining microscopy, phase imaging, and scRNA-seq to assess phenotypic resolution.

This study quantifies the energetic cost of norepinephrine signaling in primary human fibroblasts, revealing dynamic changes in glycolysis and oxidative phosphorylation over time.

The paper shows that mitochondrial DNA nucleoid distribution is controlled by pearling and cristae structure, revealing a mechanism for nucleoid spacing and segregation.

This study identifies a biophysical mechanism for mitochondrial pearling, showing it occurs spontaneously in various cell types and is driven by internal pressure or external tension.

The paper introduces miOPM, a reconfigurable LSFM platform that enables high-resolution imaging across multiple spatial scales and refractive indices.

This paper introduces an algebraic framework to model mitochondrial dynamics as groupoids and defines a distance metric for comparing mitochondrial structures based on morphological operations.

The paper introduces a framework to quantify mitochondrial specialization and plasticity using transcriptomic data across various contexts.

The paper quantifies somatic mitochondrial DNA insertions (Numts) in human brain and fibroblasts, showing their accumulation over time and association with lifespan.

MitoQuicLy quantifies cf-mtDNA in plasma, serum, and saliva with high agreement to column-based methods, showing significant inter-individual and biofluid-specific differences.

This paper introduces a computational method to improve the reliability of epigenetic clocks by using principal component analysis, showing reduced technical noise and better performance in longitudinal studies.

This study shows psychological stress increases circulating cell-free mitochondrial DNA (ccf-mtDNA) in humans through glucocorticoid signaling, with no change in nuclear DNA levels.