Kevin M. Tharp

This study shows that aging-induced CD44 in hepatocytes activates the IL6/JAK/STAT3 pathway, leading to impaired T cell function in the liver.

This study identifies a biophysical mechanism for mitochondrial pearling, showing it occurs spontaneously in various cell types and is driven by internal pressure or external tension.

This study shows FAK inhibition in ovarian tumors increases macrophage CXCL13 production via omega-3 fatty acids, enhancing B cell infiltration and immunotherapy response.

ecPath detects ecDNA in tumors using H&E images, achieving good performance in predicting ecDNA status and identifying poor prognoses in low grade glioma patients.

The paper identifies a mitochondrial redox switch that licenses the onset of morphogenesis in embryos by showing that mitochondrial superoxide production is critical for this transition.

This study investigates the impact of substrate stiffness on C. elegans health and longevity, finding only mild effects on cellular and organismal health.

This study shows that aged livers have heightened interferon signaling that suppresses cancer but also has harmful effects, leading to a 'precarious balance' in tumor development.