Author

Niko-Petteri Nykänen

Washington University in St. LouisORCID 0000-0002-3489-1441Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:proteomics· 2 Approach:statistical model· 2 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:fine-mapping· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Adelina OrellanaiD· 1 shared Agustı́n RuiziD· 1 shared Alison GoateiD· 1 shared Angela Lee JeffersoniD· 1 shared Arda CetiniD· 1 shared Brookelyn M. Doherty· 1 shared Bruno A. BeníteziD· 1 shared Carla M. YuedeiD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

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1 shared paperGenetic & Genomic Medicine

Adelina OrellanaORCID

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2 papers

Recent·Most cited

Haploinsufficiency of lysosomal enzyme genes in Alzheimers disease

Bruno A. Benítez, Clare E. Wallace, Maulikkumar Patel, Niko-Petteri Nykänen, Carla M. Yuede, Samantha L. Eaton, Cyril P. Pottier, Arda Cetin, Matthew Johnson, Mia T. Bevan, Woodrow D. Gardiner, Hannah M. Edwards, Brookelyn M. Doherty, Ryan T. Harrigan, Dominic Kurian, , Mark S. Sands

This study identifies heterozygous lysosomal enzyme gene mutations as risk factors for Alzheimer's disease and validates their impact on amyloid-beta processing using mouse models.

bioRxiv · Nov 16, 2024 · PreprintNeuroscience

Proteo-genomics of soluble TREM2 in cerebrospinal fluid provides novel insights and identifies novel modulators for Alzheimer disease

Lihua Wang, Niko-Petteri Nykänen, Daniel Western, Priyanka Gorijala, Jigyasha Timsina, Fuhai Li, Zhaohua Wang, Muhammad Ali, Chengran Yang, Menghan Liu, William Brock, Marta Marquié, Merçé Boada, Ignacio Álvarez, Miquel Aguilar, , Carlos Cruchaga

This study identifies four novel genetic loci associated with soluble TREM2 levels in CSF through GWAS and provides functional validation of their roles in Alzheimer's disease.

Molecular Neurodegeneration · Jan 3, 2024Peer-reviewedGenetic & Genomic Medicine