Author

Jigyasha Timsina

Washington University in St. LouisORCID 0000-0003-4794-9187Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 2 Bioinformatics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 4 Assay:proteomics· 3 Research Focus:differential expression· 2 Research Focus:benchmarking· 1 Assay:DNA methylation· 1 Research Focus:fine-mapping· 1 Research Focus:GWAS / association mapping· 1

Frequent Co-Authors

Carlos CruchagaiD· 4 shared Chengran YangiD· 3 shared Daniel WesterniD· 3 shared Muhammad AliiD· 3 shared Hamilton Se‐Hwee OhiD· 2 shared Lihua WangiD· 2 shared Priyanka GorijalaiD· 2 shared Tony Wyss‐CorayiD· 2 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersGenetic & Genomic Medicine

Carlos CruchagaORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

NeuroscienceNature MedicinePeer-reviewedMar 31, 2025

✦ In-depth digest

Synapse protein signatures in cerebrospinal fluid and plasma predict cognitive maintenance versus decline in Alzheimers disease

Hamilton Se‐Hwee Oh, Deniz Yagmur Urey, Linda Karlsson…·Tony Wyss‐Coray

CSF YWHAG:NPTX2 synapse protein ratio, from proteomics of 3,416 individuals across six cohorts, explains cognitive impairment beyond amyloid and tau and predicts decline (hazard ratio 15.4).

122 citationstop 1%

humanproteomics

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Genetic & Genomic MedicinemedRxivPreprintJul 23, 2024

Polygenic proxies of age-related plasma protein levels reveal TIMP2 role in cognitive performance

Federica Anastasi, Patricia Genius, Blanca Rodríguez‐Fernández…·Natàlia Vilor‐Tejedor

The paper identifies TIMP2 as a blood protein associated with improved cognitive performance in humans using polygenic scores derived from protein quantitative trait loci data.

2 citations

humanproteomics

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Genetic & Genomic MedicineMolecular NeurodegenerationPeer-reviewedJan 3, 2024

Proteo-genomics of soluble TREM2 in cerebrospinal fluid provides novel insights and identifies novel modulators for Alzheimer disease

Lihua Wang, Niko-Petteri Nykänen, Daniel Western…·Carlos Cruchaga

This study identifies four novel genetic loci associated with soluble TREM2 levels in CSF through GWAS and provides functional validation of their roles in Alzheimer's disease.

56 citationstop 1%

humanproteomics

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BioinformaticsNeurobiology of DiseasePeer-reviewedDec 9, 2023

Harmonization of CSF and imaging biomarkers for Alzheimer's disease biomarkers: need and practical applications for genetics studies and preclinicalclassification

Jigyasha Timsina, Muhammad Ali, Anh N. Do…·Carlos Cruchaga

The paper harmonizes CSF and amyloid imaging biomarkers using a Z-score approach and compares it to existing methods in GWAS analyses.

49 citations

humanstatistical model

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