Matthew Johnson

Scaling up polarization-sensitive optical coherence tomography to image the whole macaque brain

This paper develops a scalable PS-OCT system for whole-brain imaging in rhesus macaques, achieving high-resolution volumetric data with multi-terabyte datasets.

A Novel Pilus System in Candidate Phyla Radiation Bacteria

This study identifies two novel pilins, PamA and PamB, from CPR bacteria using cryo-EM, revealing unique structural and assembly features distinct from known pilus systems.

Epithelial sensing of vitamin A shapes intestinal antimicrobial defense

This study shows dietary vitamin A enhances intestinal antimicrobial defenses by promoting REG3 lectin and defensin expression through retinoic acid receptor signaling.

Exploring the diversity of anti-defense systems across prokaryotes, phages, and mobile genetic elements

The paper develops AntiDefenseFinder to detect anti-defense systems in prokaryotes, phages, and MGEs, identifying 47,981 systems and revealing their distribution and evolutionary dynamics.

Haploinsufficiency of lysosomal enzyme genes in Alzheimers disease

This study identifies heterozygous lysosomal enzyme gene mutations as risk factors for Alzheimer's disease and validates their impact on amyloid-beta processing using mouse models.

RAS-inhibiting biologics identify and probe druggable pockets including an SII-α3 allosteric site.

This paper identifies two RAS-binding Affimer proteins that inhibit RAS function and reveal a novel druggable SII/3 pocket.