Author

Federica Rinaldi

Fondazione Santa LuciaORCID 0000-0002-3501-4176Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Alessio LannaiD· 3 shared Christof StingoneiD· 1 shared Clara D’AmbraiD· 1 shared Luisa ChocarroiD· 1 shared Manuel Delpero· 1 shared Melania CapitaniiD· 1 shared Michael KariniD· 1 shared Michael Loran DustiniD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 19 mutual co-author links

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3 shared papersImmunology

Alessio LannaORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Awakening intracellular immunity for functional HIV cure

Alessio Lanna, Federica Rinaldi, Christof Stingone

This study shows that reprogramming CD4 T cells can eliminate HIV DNA reservoirs, offering a potential functional cure by restoring intracellular antiviral immunity.

bioRxiv · Jan 5, 2026 · PreprintImmunology

CD4⁺ T cells confer transplantable rejuvenation via Rivers of telomeres

Alessio Lanna, Salvatore Valvo, Michael Loran Dustin, Federica Rinaldi

The paper shows CD4 T cells release telomere-rich vesicles called Rivers, which rejuvenate senescent tissues and extend lifespan in mice.

bioRxiv · Nov 14, 2025 · PreprintCell Biology

Disruptors of sestrin-MAPK interactions rejuvenate T cells and expand TCR specificity

Alessio Lanna, Clara D’Ambra, Federica Rinaldi, Luisa Chocarro, Manuel Delpero, Melania Capitani, Michael Karin

This paper develops DOS, a first-in-class disruptor of sestrin-MAPK complexes, which rejuvenates senescent T cells and expands TCR specificity by generating new T cell clones.

bioRxiv · May 17, 2024 · PreprintImmunology