Alessio Lanna

This study shows that reprogramming CD4 T cells can eliminate HIV DNA reservoirs, offering a potential functional cure by restoring intracellular antiviral immunity.

The paper shows CD4 T cells release telomere-rich vesicles called Rivers, which rejuvenate senescent tissues and extend lifespan in mice.

This paper develops DOS, a first-in-class disruptor of sestrin-MAPK complexes, which rejuvenates senescent T cells and expands TCR specificity by generating new T cell clones.