Author

Luca Mariani

Brigham and Women's HospitalORCID 0000-0002-3502-7364Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Assay:ChIP-seq· 2 Approach:experimental assay· 2 Assay:ATAC-seq· 1 Organism:mouse· 1

Frequent Co-Authors

Martha L. BulykiD· 3 shared Henrik M. HammaréniD· 1 shared Ignacio L. IbarraiD· 1 shared In‐Young HwangiD· 1 shared Judith B. ZauggiD· 1 shared Kathryn WeinandiD· 1 shared Kwangwoon LeeiD· 1 shared Kyung‐Min NohiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersMolecular Biology

Martha L. BulykORCID

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3 papers

Recent·Most cited

Histone modifications directly modulate transcription factor binding to nucleosomes

Luca Mariani, Martha L. Bulyk

The paper investigates how histone modifications affect transcription factor binding to nucleosomes and finds that specific marks influence binding preferences and modes.

bioRxiv · Oct 23, 2026 · PreprintMolecular Biology

DNA flexibility regulates transcription factor binding to nucleosomes

Luca Mariani, Xiao Liu, Kwangwoon Lee, Stephen S. Gisselbrecht, Philip A. Cole, Martha L. Bulyk

The paper develops PIONEAR-seq to analyze TF binding to nucleosomes and finds that DNA flexibility, not TF intrinsic properties, determines binding preferences.

Nature Structural & Molecular Biology · Aug 25, 2025Peer-reviewedMolecular Biology

Comparative chromatin accessibility upon BDNF-induced neuronal activity delineates neuronal regulatory elements

Ignacio L. Ibarra, Vikram Singh Ratnu, Lucia Gordillo, In‐Young Hwang, Luca Mariani, Kathryn Weinand, Henrik M. Hammarén, Martha L. Bulyk, Mikhail M. Savitski, Judith B. Zaugg, Kyung‐Min Noh

The paper identifies BDNF-specific chromatin accessibility changes in neurons and links them to gene regulation and neurodevelopmental traits.

bioRxiv · May 28, 2021 · PreprintGenomics