The paper identifies slower protein degradation in human cells compared to mice, linking protein stability differences to interspecies variations in developmental tempo.

Developmental Cell · Aug 13, 2026Peer-reviewedDevelopmental Biology

Glycolytic flux-signaling controls mouse embryo mesoderm development

Hidenobu Miyazawa, Marteinn Thor Snaebjornsson, Nicole Prior, Eleni Kafkia, Henrik M. Hammarén, Nobuko Tsuchida-Straeten, Kiran Raosaheb Patil, Martin Beck, Alexander Aulehla

The paper shows that FBP, a glycolytic metabolite, affects mesoderm segmentation in mouse embryos by altering subcellular protein localization and Wnt-signaling.

eLife · Dec 5, 2022Peer-reviewedDevelopmental Biology

Comparative chromatin accessibility upon BDNF-induced neuronal activity delineates neuronal regulatory elements

Ignacio L. Ibarra, Vikram Singh Ratnu, Lucia Gordillo, In‐Young Hwang, Luca Mariani, Kathryn Weinand, Henrik M. Hammarén, Martha L. Bulyk, Mikhail M. Savitski, Judith B. Zaugg, Kyung‐Min Noh

The paper identifies BDNF-specific chromatin accessibility changes in neurons and links them to gene regulation and neurodevelopmental traits.

bioRxiv · May 28, 2021 · PreprintGenomics