Kwangwoon Lee

The paper shows that inhibiting the CoREST complex with corin alters RNA splicing, increases neoantigen expression, and enhances tumor immunity in melanoma.

The paper develops PIONEAR-seq to analyze TF binding to nucleosomes and finds that DNA flexibility, not TF intrinsic properties, determines binding preferences.

This paper identifies UM171 as a molecular glue that promotes degradation of HDAC1/2 complexes by inducing asymmetric interactions between KBTBD4 and HDAC1.

This paper introduces an engineered sortase, cW11, for modifying and isolating histone H3 tails to study epigenetic modifications and their effects on enzyme processing and protein recognition.