Xiao Liu

The paper identifies a GC-independent memory B cell subset derived from B1 cells that contributes to protective immunity against viral infection.

The paper investigates how B cell affinity affects germinal center (GC) responses by showing high-affinity B cells have shorter GC residence times and lower-affinity B cells are maintained, suggesting an antibody feedback mechanism that modulates affinity and epitope spreading.

The paper develops PIONEAR-seq to analyze TF binding to nucleosomes and finds that DNA flexibility, not TF intrinsic properties, determines binding preferences.

This study shows that a single immunization with a germline-targeting trimer can induce broad HIV-1 neutralizing antibodies in a rhesus macaque bnAb mouse model.