Author

Thomas K. Creson

Scripps Research Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Neuroscience· 4

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1

Frequent Co-Authors

Camilo RojasiD· 4 shared Courtney A. MilleriD· 4 shared Gavin RumbaughiD· 4 shared Àlex BayésiD· 2 shared Aliza A. LeiD· 2 shared Brent WilkinsoniD· 2 shared Gemma GouiD· 2 shared Marcelo P. CobaiD· 2 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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4 shared papersNeuroscience

Camilo RojasORCID

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4 papers

Recent·Most cited

Syngap1 Promotes Cognitive Function through Regulation of Cortical Sensorimotor Dynamics

Thomas Vaissière, Sheldon D. Michaelson, Thomas K. Creson, Jessie Goins, Daniel Fürth, Diána Balázsfi, Camilo Rojas, Randall M. Golovin, Konstantinos Meletis, Courtney A. Miller, Daniel H. O’Connor, Lorenzo Fontolan, Gavin Rumbaugh

This study shows that Syngap1 in cortical neurons is essential for sensorimotor integration and perception by shaping neural dynamics and connectivity.

Nature Communications · Jan 18, 2025Peer-reviewedNeuroscience

Endogenous Syngap1 Alpha Splice Forms Promote Cognitive Function and Seizure Protection

Murat Kilinc, Vineet Arora, Thomas K. Creson, Camilo Rojas, Aliza A. Le, Julie Lauterborn, Brent Wilkinson, Nicolas Hartel, Nicholas Graham, Adrian Reich, Gemma Gou, Yoichi Araki, Àlex Bayés, Marcelo P. Coba, Gary Lynch, , Gavin Rumbaugh

The paper shows that specific SynGAP splice variants improve cognitive function and reduce seizures in mice.

eLife · Apr 8, 2022Peer-reviewedNeuroscience

Splicing of the SynGAP Carboxyl-Terminus Enables Isoform-Specific Tuning of NMDA Receptor Signaling Linked to Cognitive Function

Murat Kılınç, Thomas K. Creson, Camilo Rojas, Sabyasachi Maity, Aliza A. Le, Julie C. Lauterborn, Brent Wilkinson, Nicolas G. Hartel, Nicholas Alexander Graham, Adrian M. Reich, Gemma Gou, Yoichi Araki, Àlex Bayés, Marcelo P. Coba, GARY S. LYNCH, , Gavin Rumbaugh

The paper investigates how the SynGAP-1 PBM regulates NMDA receptor signaling and cognitive function in mice, finding that disrupting the PBM leads to synaptic and cognitive impairments.

bioRxiv · Jan 18, 2020 · PreprintNeuroscience

Re-expression of SynGAP Protein in Adulthood Improves Translatable Measures of Brain Function and Behavior in a Model of Neurodevelopmental Disorders

Thomas K. Creson, Camilo Rojas, Ernie Hwaun, Thomas Vaissière, Murat Kılınç, Andrés Jiménez-Gómez, Jimmy Lloyd Holder, Jianrong Tang, Laura Lee Colgin, Courtney A. Miller, Gavin Rumbaugh

This study shows that restoring SynGAP protein in adult Syngap1 heterozygous mice improves memory, seizure susceptibility, and brain activity patterns.

eLife · Apr 26, 2019Peer-reviewedNeuroscience