Aliza A. Le

Early-life Oxytocin Rescues Hippocampal Synaptic Plasticity and Episodic Memory in a Mouse Model of Fragile X Syndrome

Metabotropic NMDA Receptor Signaling Contributes to Sex Differences in Synaptic Plasticity and Episodic Memory

The paper shows sex-specific roles of metabotropic NMDA receptor signaling in synaptic plasticity and episodic memory in mice.

Contrasting synaptic roles of MDGA1 and MDGA2

The paper investigates the distinct synaptic roles of MDGA1 and MDGA2, showing MDGA1 modulates excitatory synapses while MDGA2 affects inhibitory synapses.

Microglia Depletion Selectively Eliminates a Singular Form of Hippocampal Long Term Potentiation

The paper shows that microglia depletion selectively impairs a specific form of hippocampal long-term potentiation (LTP) in the lateral perforant path.

Signal Transformations and New Timing Rules of Hippocampal CA3 to CA1 Synapses

The paper derives input-output transformation functions for hippocampal CA3 to CA1 synapses using Volterra expansion, revealing timing rules and differences between apical and basal dendrites.

Endogenous Syngap1 Alpha Splice Forms Promote Cognitive Function and Seizure Protection

The paper shows that specific SynGAP splice variants improve cognitive function and reduce seizures in mice.

Splicing of the SynGAP Carboxyl-Terminus Enables Isoform-Specific Tuning of NMDA Receptor Signaling Linked to Cognitive Function

The paper investigates how the SynGAP-1 PBM regulates NMDA receptor signaling and cognitive function in mice, finding that disrupting the PBM leads to synaptic and cognitive impairments.

Acquisition of Temporal Order Involves a Reverberating Network in Hippocampal Field CA3

This study shows that hippocampal CA3 maintains self-sustained activity and is critical for acquiring temporal order in odor memory, but not odor identity or location.