Heather A. Lawson

Leveraging Human Pangenome for Improved Somatic Variant Detection

This study shows that using graph-based pangenomes and inferred donor-specific assemblies improves somatic variant detection compared to GRCh38.

Genetic, epigenetic, and environmental mechanisms govern allele-specific gene expression

The paper investigates how genetic, epigenetic, and environmental factors influence allele-specific gene expression in mice, identifying tissue- and context-dependent patterns and inconsistent ASE biases.

Parent-of-origin effects propagate through networks to shape metabolic traits

The paper identifies a network of imprinted and non-imprinted genes that propagate parent-of-origin effects on metabolic traits through epistatic interactions in mice.

Integrated transcriptomics identifies β-cell subpopulations and genetic networks associated with obesity and glycemic control in SM/J mice

This study integrates single-cell and bulk RNA sequencing data from SM/J mice to identify β-cell subpopulations and genetic networks linked to obesity and glycemic control.

TRAP-based allelic translation efficiency imbalance analysis to identify genetic regulation of ribosome occupancy in specific cell types in vivo.

The paper uses TRAP to analyze allelic translation efficiency imbalance in mouse astrocytes, finding that some genetic variants affect ribosome occupancy independently of transcript abundance.

Genetic background and diet affect brown adipose gene co-expression - metabolic associations

The paper identifies gene networks in brown adipose tissue of mice that are influenced by genetic background and diet, linking them to obesity and diabetes traits.

Epistatic Networks Associated with Parent-of-Origin Effects on Metabolic Traits

The paper identifies epistatic gene interactions underlying parent-of-origin effects on metabolic traits in mice using reciprocal crosses and tissue-specific expression analysis.