MALDI-TOF mass spectrometry and proteomics as phenotypic screening tools for anti-inflammatory drugs
Leonie Müller, Serena Bateman, Charlie Haslam, Thomas K. Dawson, Denise F. Vlachou, Evan Rosa-Roseberry, Lee M. Booty, Chloe L. Tayler, Andrew Michael Frey, Roland S. Annan, Melanie V. Leveridge, María Emilia Dueñas, Rachel E. Heap, Matthias Trost
This study evaluates two mass spectrometry-based phenotypic screening approaches for identifying anti-inflammatory compounds in macrophages and compares them to cytokine profiling.
bioRxiv · Dec 3, 2025 · PreprintBiochemistry