María Emilia Dueñas

The paper identifies how mistargeted mitochondrial proteins are rerouted to the ER and cleared via ERAD, with MARCHF6 playing a central role in maintaining proteostasis during mitochondrial dysfunction.

This study evaluates two mass spectrometry-based phenotypic screening approaches for identifying anti-inflammatory compounds in macrophages and compares them to cytokine profiling.

The paper identifies CTDNEP1-NEP1R1 as the R-SMAD phosphatase and shows how its complex with MAN1 inactivates TGF-β signaling by dephosphorylating R-SMADs in the nucleus.