Intracellular barriers and receptor masking limit success of a Pseudomonas aeruginosa clinical phage family
Wearn‐Xin Yee, Amy B. Banta, Ryan David Ward, Sriharshita Musunuri, M.-Y. Liu, Erin D. Huiting, Julia Gordeeva, Suzanne C. Letham, Tanmay A. M. Bharat, Jason M. Peters, Joseph Bondy‐Denomy
The paper identifies surface receptor masking and internal defenses as barriers to phage therapy in Pseudomonas aeruginosa clinical isolates and presents strategies to overcome these barriers through phage engineering.
bioRxiv · Jun 18, 2026 · PreprintMicrobiology